College Football Odds, Picks, Lines, Bets, Predictions for Week 6, 2024: Proven Model Supports Iowa, California

The Alabama Crimson Tide were expected to take a slight step backwards this season under first-year head coach Kalen DeBoer, but they are atop the AP Poll heading into the Week 6 college football schedule . They achieved a dramatic victory over the then number one team. 2 Georgia, and they’re a 24-point away favorite against Vanderbilt in the Week 6 college football odds, according to the SportsLine consensus. Vanderbilt is coming off two straight road losses, but had an extra week to prepare for this game, after suffering two overtime defeats at the then No. 1 team. 7 Missouri. Should you place your college football bets on the Commodores as big underdogs in Week 6?

Other top five teams playing Saturday include No. 3 Ohio State (-20.5) vs. Iowa, No. 4 Tennessee (-13.5) at Arkansas and No. 5 Georgia (-23, 5) against Auburn. This weekend’s Top 25 schedule begins Friday when No. 25 UNLV (-4.5) hosts Syracuse and No. 6 Oregon (-24) takes on Michigan State. Before you finalize your Week 6 college football picks for these or any other games, be sure to check out the latest college football predictions from SportsLine’s trusted model.

The model simulates every FBS college football game 10,000 times. Since its inception, its top-rated college football picks against the spread have generated well over $2,000 in profits for $100 players. It’s also coming off a profitable 13-9 season with top spread picks. Anyone who has followed it has seen strong returns.

Now it has turned its attention to the latest college football odds and Week 6 college football betting lines on the spread, moneyline and over/under. Head here to see each selection.

The best college football predictions for Week 6

One of the college picks the model has at the top in Week 6: Iowa (+20.5) remains in the wide spread at No. 3 Ohio State in a 3:30 p.m. ET matchup on Saturday. The Buckeyes find themselves in a disappointing position as they return home after a blowout win at Michigan State last week, and they have a big game against No. 6 Oregon next week. They face an Iowa team that enters the week with momentum after comfortable wins over Troy and Minnesota.

Hawkeyes junior running back Kaleb Johnson had a monster game against Minnesota, finishing the game with 206 rushing yards and three touchdowns on 21 carries. Johnson has recorded at least 119 rushing yards and two touchdowns in all four games this season, so Ohio State will have difficulty controlling the pace of Saturday’s game. The Buckeyes have covered the spread just twice in their last six games, and SportsLine’s model has Iowa covering it in over 60% of simulations. Find the rest of the Week 6 college football picks here.

Another prediction: California (+11.5) plays a one-score game against No. 8 Miami on Saturday at 10:30 p.m. ET. The Hurricanes narrowly avoided a major upset last week, defeating Virginia Tech in a 38-34 final as 17.5-point favorites. They have covered the spread just four times in their last 17 conference games, making them a team that fades on the road after this emotional victory.

California had its three-game winning streak ended in its last game with a 19-14 loss to Florida State, but had an extra week to recover after that game. Sophomore quarterback Fernando Mendoza has thrown for 892 yards and five touchdowns, with four of his receivers reaching the 100-yard mark. The Golden Bears have won five of their last seven home games and are covering the spread in well over 60% of the latest simulations. The tips for every other game in Week 6 can be found here.

How to make college football picks for Week 6

The model has also determined who will win and cover in each FBS matchup in Week 6, and it projects a whopping seven underdogs to win outright, including an upset in one of the biggest games of the week. Only at SportsLine can you get every pick for every game.

So which college football picks can you make with confidence and which seven underdogs will win outright in Week 6? Check out the latest college football odds below, then visit SportsLine to see which teams are winning and covering the spread, all using a proven computer model that has returned well over $2,000 in profits since its inception has, and find out.

College football odds for Week 6

Complete college football picks, odds and predictions for Week 6 can be found here

Thursday, October 3rd

Texas State at Troy (+15, 58)

Sam Houston State at UTEP (+10.5, 50)

Friday, October 4th

Jacksonville State at Kennesaw State (+14, 48.5)

Houston at TCU (-17, 49.5)

Syracuse at UNLV (-4.5, 58)

Michigan State at Oregon (-24, 52.5)

Saturday, October 5th

Missouri at Texas A&M (-1.5, 49.5)

UCLA at Penn State (-28.5, 44.5)

Auburn at Georgia (-23.5, 52)

Ole Miss at South Carolina (+9, 51.5)

Iowa at Ohio State (-20.5, 44.5)

Alabama at Vanderbilt (+24, 55)

Clemson at Florida State (+14.5, 47)

Baylor at Iowa State (-13, 46)

USC at Minnesota (+8.5, 52)

Michigan at Washington (-3, 40.5)

Miami in California (+11.5, 55)

Texas Tech at Arizona (-5, 62.5)